Broadly neutralizing human monoclonal antibodies to the hepatitis C virus E2 glycoprotein
نویسندگان
چکیده
منابع مشابه
Broadly neutralizing human monoclonal antibodies to the hepatitis C virus E2 glycoprotein
The humoral response to hepatitis C virus (HCV) may contribute to controlling infection. We previously isolated human monoclonal antibodies to conformational epitopes on the HCV E2 glycoprotein. Here, we report on their ability to inhibit infection by retroviral pseudoparticles incorporating a panel of full-length E1E2 clones representing the full spectrum of genotypes 1-6. We identified one an...
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Hepatitis C virus (HCV) remains a significant threat to the general health of the world's population, and there is a pressing need for the development of new treatments and preventative vaccines. Here, we describe the generation of retrovirus-based pseudoparticles (HCVpp) incorporating a panel of full-length E1E2 clones representative of the major genotypes 1 through 6, and their application to...
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The relative importance of humoral and cellular immunity in the prevention or clearance of hepatitis C virus (HCV) infection is poorly understood. However, there is considerable evidence that neutralizing antibodies are involved in disease control. Here we describe the detailed analysis of human monoclonal antibodies (MAbs) directed against HCV glycoprotein E1, which may have the potential to c...
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ژورنال
عنوان ژورنال: Journal of General Virology
سال: 2008
ISSN: 0022-1317,1465-2099
DOI: 10.1099/vir.0.83386-0